Understanding disease in the digital age


OccamzRazor is a digital biotech company that focuses on the discovery and development of modality agnostic treatments for complex diseases of brain aging. Founded by life scientists, OccamzRazor strives to supercharge human scientific reasoning through machine learning. Our integration of various machine learning techniques, such as natural language processing and graph representation learning allows us to process an unprecedented amount of high-quality data and combine it into a multidimensional knowledge map. OccamzRazor’s platform identifies disease targets and mechanisms better than any other solution as showcased at the 2020 NeurIPS conference.

OccamzRazor’s approach combines previously siloed knowledge into one unified knowledge map to identify new therapeutic avenues for brain aging diseases.

OccamzRazor’s approach combines previously siloed knowledge into one unified knowledge map to identify new therapeutic avenues for brain aging diseases.


 

We have more and better data than ever, yet clinical success is in decline.


The exponential increase of public knowledge does not translate into clinical trial success. The last decades were full of scientific breakthroughs. Over 100,000 human genomes were sequenced to date, new technologies such as CRISPR-CAS9 enable scientists to produce more high-quality data than ever. What stops us from converting that data into actionable insights for treatment options? The human capacity to cut through the vast data repositories and draw the right connections is limited. OccamzRazor is solving this problem.


More papers are published every year than any human can read and keep in mind. Conversely, clinical trials in diseases of the central nervous system (CNS) are failing at increasing rates, leaving patients of complex diseases with no options for cura…

More papers are published every year than any human can read and keep in mind. Conversely, clinical trials in diseases of the central nervous system (CNS) are failing at increasing rates, leaving patients of complex diseases with no options for curative treatment.

 

Our digital scientist technology combines knowledge extraction and graph learning

 “Labeled training data is the new new oil.” 
Christopher Ré, Stanford

Together, with world leading experts from Stanford University, we developed a data labeling system to vastly accelerate
the generation of Natural Language Processing (NLP) classifiers for biomedical knowledge extraction.

OccamzRazor’s Natural Language Processing (NLP) pipeline reasons from text and uses the wealth of scientific literature to inform our proprietary knowledge map.

Building on this technology, OccamzRazor developed the first end-to-end insight prediction pipeline. It allows us to automatically draw knowledge from millions of peer-reviewed publications, high-quality proprietary datasets, clinical trial findings, and our own lab experiments. The seamless integration of text-based and structured datasets in one knowledge map is the basis for our innovative approach to drug discovery.


Our dynamic knowledge map technology acts as a digital scientist and provides new insights for various diseases. The importance of automatically integrating text-based data to find new disease mechanisms and drug targets is a breakthrough finding that we proudly present at the 2020 NeurIPS conference.


 
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Our key to success: A vast diversity of data brought together in one unified platform and cutting edge machine learning.

We start our discovery journey where purely human reasoning reaches its limits. Our algorithms can operate in hundreds of dimensions of information combining proteomics, genomics, imaging, and patient data to predict new ways to cure disease. After thorough digital evaluation and de-risking, we test these hypotheses in our own proprietary disease models. Our approach is extremely versatile and lean as it does not require us to set up a laboratory before we have a list of high potential disease targets in hand.

Together with our partners we keep pushing the boundaries of technology to give hope to millions of patients and their families and develop the first treatments to cure Parkinson’s disease and other brain-aging diseases. We have entered the pre-clinical stage of our first AI-generated therapies.

 

team

 
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Jonathan Deans, PhD

Senior Computational Biologist

Jonathan received his PhD in Genetics, Genomics, and Bioinformatics from the University of California, Riverside, studying the impact of genetic variation on nuclear receptor DNA binding affinity and its relation to tissue-specific gene expression. His 15+ years of experience cover various areas of bioinformatics research, such as de novo gene predictions in Plasmodium falciparum.

 
 
 
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Afshan Nabi

Machine Learning Engineer

Afshan completed her MS in Computer Science from Sabanci University and her BS in Molecular Biology & Genetics from Bilkent University. She is interested in applying machine learning to solve problems in computational biology. Her previous projects include identifying coding lncRNAs using deep learning and predicting DNA repair levels using histone modifications.

 
 
 


Justina Concepcion

Executive Assistant

Joining OccamzRazor as the Executive Assistant to the CEO, Justina brings with her years of experience as an administrative professional in the Media and Tech industries. An avid reader, Justina holds a Bachelor and Master of Arts in English Literature.

 
 
 
 
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William Koehler

Senior Engineer

After graduating with a BS in Statistics with an emphasis on Computer Science from the University of Illinois, Urbana-Champaign, William began research with postdocs at Stanford University in computational biology and gathering -omics data. His work recently published in the “American Heart Association” and “F1000”.

 
 

Leadership

OccamzRazor is an international assembly of biomedical scientists, bioinformaticians, and AI experts.

We value team spirit, humility, and constant learning. Since we come from various industrial and academic avenues, we foster a culture of constant exchange and mutual support to achieve our ambitious goals together.

 

Dr. Robbie Narang

CEO

Robbie brings over a decade of operations experience in diagnostics development and laboratory automation for drug discovery. He joined OccamzRazor from Notable Labs, where he was Chief Operating Officer. Prior to that, he served on the Ways and Means Committee, Subcommittee on Health as a Congressional Innovation Fellow and was a member of the assay development group at IntelliCyt, which was successfully acquired by Sartorius. He received his Ph.D. in Molecular Microbiology from Tufts University and his B.S. in Biology from the University of New Mexico.

 
 
 

Dr. Katharina Sophia Volz

Founder, Executive Chair of the Board, and VP of Partnerships

Katharina was Stanford University's first PhD in Stem Cell Biology & Regenerative Medicine, earning her degree in just two and a half years. Her experience in biomedical research covers over 16 years working in labs at 10 prestigious institutions around the world, including: Harvard, UCLA, HHMI, Ohio State, TU Graz and Stanford University. For her scientific work, Katharina has been awarded multiple fellowships and awards and was listed in Forbes 30u30 (Science) in 2017.

 
 
 
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Dr. Spyros Papapetropoulos

Chief Development Officer and Strategic Advisor

Spyros is a Pharma and Biotech veteran. He is the former CEO at SwanBio Therapeutics. Prior to that, he served as Head of Research & Development and CMO at Cavion Inc. Before Cavion, he was the Medical Director at Biogen, Allergan, and Pfizer. As one of the leading experts in Parkinson’s Disease, he has over 170 relevant publications. Spyros holds appointments as Consultant with Mass General and Voluntary Professor of Neurology with the University of Miami, Miller School of Medicine.

 
 
 

Dr. Berk Kapicioglu

Chief Technology Officer

Berk joined OccamzRazor from Foursquare Labs, where he was their head of machine learning. Prior to that, he worked at Google and the location intelligence startup Sense Networks. He received his PhD from the computer science department at Princeton University, and his BA from the computer science, mathematics, and philosophy departments at the University of Pennsylvania. His work has been published at venues such as AISTATS, UAI, IJCAI, RecSys, and NeurIPS.

 
 
 

Advisors

OccamzRazor is proud to draw on the experience and expertise of some of the sharpest minds in both medical science and AI.
Our advisors are leaders in all aspects of our business and support us with key insight.

 

PROF. RANDY SCHEKMAN

Nobel laureate in Physiology or Medicine, Director of ASAP Parkinson’s program



PROF. ED BOYDEN

MIT Neurotechnology Professor; Winner Breakthrough Prize for discovery of Optogenetics


ALEXANDER LEVY

Co-founder of AI-drug discovery company Atomwise

 

CARROLEE BARLOW, MD, PhD

CMO at E-ScapeBio, former Prof. for neurogenomics at SALK institute, former CEO at Parkinson’s Institute and Clinical Center


PROF. AGNIESZKA CZECHOWICZ, MD, PhD

Prof. at Stanford, VC at Google Ventures, Co-founded six Biotech companies

investors

 

JEFF DEAN (Lead Investor)

Lead of Google AI, Founder and Lead of Google Brain

RE.MIND VC

Fund focused on mental health


JEFF HAMMERBACK via Techammer

Focus on ML and science

 

LAUDER PARTNERS

Focused on radical innovation

PHIL LIBIN

Co-founder & former long-term CEO of Evernote; CEO at AI firm All Turtles

TOM GLOCER, JD

Former long-term CEO of Thomson Reuters; Board of Directors at Merck

 
 

OccamzRazor is a resident company of Johnson & Johnson Innovation – JLABS, a premier life science incubator program. JLABS is a global network of open innovation ecosystems, enabling and empowering innovators to create and accelerate the delivery of life-enhancing health and wellness solutions to patients around the world. As a leader in innovation, JLABS helps entrepreneurs in pharmaceutical, medical device, consumer, and health tech bring healthcare solutions to patients and consumers.

 
 

NEWS & UPDATES

OccamzRazor is always looking to push the boundaries of medical research and to find solutions to complex disease areas.

If you would like to keep up to date with our latest developments, please visit News & Updates and sign up below to join our mailing list.

You can find OccamzRazor on social media here:

 

 JOIN THE TEAM

This is a very exciting time for OccamzRazor. We are expanding rapidly and looking for people who want to share the journey.
Our internal culture is open and collaborative, we’re creating a space everyone can feel proud to contribute to.

Currently, we have a range of openings, but we are also happy to welcome speculative applications.

Current vacancies

 

 get in touch

As a forward looking company, we know that to retain our competitive edge we will form new partnerships and gain new investment in the future.

If you would like to make a preliminary enquiry or get in touch with our team please use the link below.